NSP13 Nucleotide site ligands
Initial druggability analysis indicates both nucleotide and DNA/RNA binding pockets as being druggable, and amongst the most well conserved pockets in the entire SARS-CoV-2 genome.
Info about mechanism of Nucleic Acid Unwinding by SARS-CoV Helicase from SARS-CoV1: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036521 - “experimental evidence that nsp13 and nsp12 can function in a concerted manner to improve the efficiency of viral replication and enhance our understanding of nsp13 function during SARS-CoV RNA synthesis”
